KNOXVILLE, TN (July 14, 2021) – The Southern Professional Hockey League (SPHL) announced Wednesday that after playing a reduced 42-game schedule with five teams in 2020-2021, the league will drop the puck for its 18th season on Friday, October 15 with 11 teams playing a full 56-game schedule.
| Day | Date | Visitor | Home | |
| Friday | October 15, 2021 | Macon | @ | Knoxville |
| Friday | October 22, 2021 | Knoxville | @ | Birmingham |
| Saturday | October 30, 2021 | Roanoke | @ | Knoxville |
| Sunday | October 31, 2021 | Huntsville | @ | Knoxville |
| Friday | November 5, 2021 | Fayetteville | @ | Knoxville |
| Saturday | November 6, 2021 | Knoxville | @ | Fayetteville |
| Sunday | November 7, 2021 | Knoxville | @ | Fayetteville |
| Wednesday | November 10, 2021 | Knoxville | @ | Huntsville |
| Friday | November 12, 2021 | Knoxville | @ | Evansville |
| Saturday | November 13, 2021 | Knoxville | @ | Macon |
| Friday | November 19, 2021 | Vermilion | @ | Knoxville |
| Saturday | November 20, 2021 | Knoxville | @ | Vermilion |
| Wednesday | November 24, 2021 | Birmingham | @ | Knoxville |
| Friday | November 26, 2021 | Birmingham | @ | Knoxville |
| Friday | December 3, 2021 | Knoxville | @ | Birmingham |
| Sunday | December 5, 2021 | Knoxville | @ | Fayetteville |
| Friday | December 10, 2021 | Knoxville | @ | Peoria |
| Saturday | December 11, 2021 | Knoxville | @ | Peoria |
| Friday | December 17, 2021 | Macon | @ | Knoxville |
| Saturday | December 18, 2021 | Macon | @ | Knoxville |
| Sunday | December 26, 2021 | Roanoke | @ | Knoxville |
| Thursday | December 30, 2021 | Knoxville | @ | Huntsville |
| Friday | December 31, 2021 | Pensacola | @ | Knoxville |
| Saturday | January 1, 2022 | Pensacola | @ | Knoxville |
| Saturday | January 8, 2022 | Vermilion | @ | Knoxville |
| Tuesday | January 11, 2022 | Knoxville | @ | Huntsville |
| Friday | January 14, 2022 | Knoxville | @ | Macon |
| Saturday | January 15, 2022 | Knoxville | @ | Macon |
| Sunday | January 16, 2022 | Evansville | @ | Knoxville |
| Friday | January 21, 2022 | Fayetteville | @ | Knoxville |
| Saturday | January 22, 2022 | Vermilion | @ | Knoxville |
| Friday | January 28, 2022 | Knoxville | @ | Vermilion |
| Saturday | January 29, 2022 | Knoxville | @ | Quad City |
| Sunday | January 30, 2022 | Knoxville | @ | Quad City |
| Thursday | February 3, 2022 | Knoxville | @ | Birmingham |
| Friday | February 4, 2022 | Huntsville | @ | Knoxville |
| Saturday | February 5, 2022 | Knoxville | @ | Roanoke |
| Thursday | February 10, 2022 | Peoria | @ | Knoxville |
| Friday | February 11, 2022 | Knoxville | @ | Pensacola |
| Saturday | February 12, 2022 | Knoxville | @ | Pensacola |
| Thursday | February 17, 2022 | Knoxville | @ | Macon |
| Saturday | February 19, 2022 | Fayetteville | @ | Knoxville |
| Sunday | February 20, 2022 | Fayetteville | @ | Knoxville |
| Friday | February 25, 2022 | Roanoke | @ | Knoxville |
| Saturday | February 26, 2022 | Roanoke | @ | Knoxville |
| Friday | March 4, 2022 | Huntsville | @ | Knoxville |
| Saturday | March 5, 2022 | Knoxville | @ | Birmingham |
| Friday | March 11, 2022 | Quad City | @ | Knoxville |
| Saturday | March 12, 2022 | Quad City | @ | Knoxville |
| Thursday | March 17, 2022 | Peoria | @ | Knoxville |
| Friday | March 25, 2022 | Birmingham | @ | Knoxville |
| Saturday | March 26, 2022 | Knoxville | @ | Birmingham |
| Friday | April 1, 2022 | Knoxville | @ | Roanoke |
| Saturday | April 2, 2022 | Knoxville | @ | Roanoke |
| Friday | April 8, 2022 | Knoxville | @ | Evansville |
| Saturday | April 9, 2022 | Evansville | @ | Knoxville |